Hotel Tour - the Evaluation Essay Example for Free

Hotel Tour the Evaluation Essay Remington Hotel is located near NAIA 3, beside the Resorts World Manila. The hotel is good but has some flaws that has a need to work on knowing the hotel is rated as 4-star. As a hotel, they must repair and maintain facilities as it is needed. But when we arrived to the hotel, one of their interior design is not functioning, which is a demerit for their hotel. And no personnel from the department of repair is fixing it. The hallway of the hotel is very simple, as a 4-star hotel, being classy yet elegant is a must, but then, we felt like we are in a dormitory as we walked through the hallway and corridors. The elevator is well functioning, the good thing about their elevator is their ving card system, where in a guest can only go to a certain floor where his/her room is located. The room is okay. I cannot say that is very good since it doesn’t has a mini bar which is one of the requirements of a guest room, also, the bathroom is not spacious, and it does not have a bath tub. Also, I did not saw their spa and gym, which I doubted they have as well as their convention halls. Their personnel are accommodating, good looking, and practice being hygienic. The female personnel’s hair are in bun, they wear a light make up, and proper uniform, while men personnel’s hair are properly trimmed, and they wear proper uniform. Another thing I am concerned with is their reception area is far from the doors of the hotel. Which I think will not work because the guests will still look for it instead of seeing it upon entering the hotel. Resorts World Manila is such a very elegant, luxurious place for unwinding, relaxation, and of course, for entertainment. It is an all in one establishment. It has a casino, a lineup of first class bars and clubs, restaurants, and the Newport mall. But, there are some downsides. In order to enter the establishment, you must be 18 years old and above, or accompanied by an adult, you must have enough money to roam around the vicinity, of course, this is a place for rich people. The Seminars we attended when we had our hotel tour is very beneficial for each and every one of us students especially when we already entered the Tourism and Hospitality Industry. From Meal Management, though it is not that good because it is very basic, and it has been already discussed by our dearest Prof. Elizabeth Guevarra. It is beneficial for us in the sense that when we wanted to enter FB sector, we know how to operate it and how we can serve our guests finely. We are able to serve them in the best way. In FB sector, mastery of the skills is a must in order to get appreciated by the large number of guests coming in to your food establishment. The Purchasing and Cost Control Seminar we had at Genting Star Tourism Academy (GSTA) is very helpful for us when we chose to have our own food establishment in the near future or we want to be a purchaser of a restaurant or in the hotel. We can use what we learned form the seminar to fit in with the standards of being a certified purchaser or a food establishment owner. The Front Office Management seminar we had again, at GSTA, is one of my favorite seminars we had, we learned a lot, and it is very beneficial and favorable for some who wants to be in front desk of a hotel or Cruise ship. We learned that there is a separate reservation system from hotel and cruise ship. There is Opera Full Service, and Fidelio Cruise. Both used as a reservation system and it is easy to use. The House Keeping Seminar we had at GSTA helped us a lot since we knew that lots of General Managers or at least top employees in the hotel are from the housekeeping department because they know most of the circulations in the hotel. In the lecture, the speaker told us that as a house keeper who needs to make up 16 rooms in 2 hours, he must acquire a number of assistant to help the house keeper out and not making himself being in a hurry. When cleaning a guest room, a house keeper must clean first the ceiling, then the walls, and lastly the floor. As we had our bed making demonstration from one of the graduates and employee of GSTA, we learned that when you make the bed, you must work complementing being fast and working with grace. To be more efficient, a housekeeper must work in the way that he/she will be more comfortable with. We learned that it is much easier to miter the linens if you use your knees to lift the mattress. Also, a house keeper must wear comfortable clothes to move freely and make the bed very well. After the said demonstration about housekeeping, we got the chance to try making our own beds in our hotel rooms. When we get back to our respective rooms, we are ordered to make the bed and take pictures for documentations. But sadly, the house keeper and other staffs of Remington Hotel and Marsman Drysdale designated 15 students in one bed which made us a bit annoyed because we will not be able to execute our trial very well. Here’s our photo documentation for bed making: My roommates are Jerome Paul Misa and Richard Mark Oliveros. Martin Tioseco is not our roommate but he decided to have his bed making trial with us since the employees are rushing us and we have no time to make the bed group by group. a.Before Return-Demonstration Procedures b. While working on Bed Making Procedures c. Finish Product of a Well-Made Bed Set-up The theme park is not just for Lodging, Casino, Malls, and Bars, they also have the Newport Performing Arts Theatre in where we watched the King and I show, it is also a great experience for us to enter the theatre of Resorts World Manila. Also, they offer free shuttle service for guests who checked-in in their corresponding hotels: Maxims Hotel, Marriott Hotel, and Remington Hotel. Also, it is offered free for Resorts World Member which we got on the night of day 1. Resorts World Manila offers free membership card for everyone to earn points and as an ID to enter the Resorts World Manila.

Effect of Parasite Diversity and Age on Antibody Responses

Effect of Parasite Diversity and Age on Antibody Responses This study was aimed at investigating the effect of parasite diversity and age on the levels of antibody responses to P. falciparum in individuals living in an area of seasonal malaria transmission. Two blood stage antigens (MSP1(19), AMA1) and two liver stage antigens (CSP and celTOS), making a total of four antigens were selected to be used for the study. These antigens were tested in archived plasma samples with ages ranging from 1year to 70 years. The samples were collected close to the end of the rainy season in the months of November and December (wet season), and April the following year at the end of the dry season (dry season). Of the samples collected in the wet season, 34.1% had parasites whiles those collected in the dry season was 15.5% (table 1). Appawu (2004) reported the seasonality of malaria transmission in a neighbouring district (Kasena Nankana District), being high in the wet season and low in the dry season. The high transmission in the wet season could be due to favourable breeding grounds for mosquitoes as a result of several collections of water when it rains and in turn increase the number of vectors and hence the high number of parasites individuals are exposed to (Ahmed, 1989). This data is in agreement with an earlier finding in northern Ghana by Apawu and his group where they found high parasite carriage, and high multiplicity of infection (MOI) in the wet season compared to low carriage and MOI in the dry season. Parasite carriage here means the proportion of participants with P. falciparum at enrolment. There was however no statistically significant difference in the parasite densitie s when compared between the seasons (p=0529) table 1. There was no difference in the overall ages between the wet and the dry season. (p=0.937). This was expected as most of the samples collected were from the same individuals in the two seasons. To explore age related pattern of P. falciparum infection, participants were categorized into three (3) age groups: under 5 years, between 5 and 15 years, and over 15 years. The data shows the 5-15 year olds having higher infected proportion in the two seasons (table 2). Parasitaemia was also determined using a more sensitive method, the polymerase chain reaction (PCR). The PCR data confirmed the microscopy data because the 6-15 year group also had higher proportion of individuals carrying parasites at enrolment. This could be due to the fact that they are the more exposed group with incompletely developed immune systems. In contrast, under-fives who are much younger are likely to receive better care from parents thus preventing them from being infected with the parasites. Bed net usage could be one way of protecting the children. Also because of their younger ages they may not be allowed roam around freely. Adults on the other hand despite having possible similar exposure as 5-15 ye ar olds, seem to have less parasites because of their developed anti-malarial immunity. This partial immunity is gained with age and repeated exposure thus making the younger individuals more susceptible to infection (Pratt-Riccio et al., 2005; Dodoo et al., 2008). Thus the over 15 year group who are older, had the least proportion of infection (table 2). The study also sought to determine the relationship between IgG levels and age. Figures fig 7 and 8 shows the correlation plots between age and IgG levels in the wet and dry season respectively. There was a significant positive correlation between and IgG levels raised against AMA1-FVO, MSP1, CSP and CelTOS in the wet season. And for the dry season, the significant correlation was between age and IgG levels to AMA1-FVO, MSP1, CSP, and Celtos. The correlation coefficient (r2) and the p values are indicated on each plot. There was however no correlation between age and AMA1-3D7 (r2 0.0142, p 0.0699) for the wet season, and AMA1-FVO (r2=0.0114, p= 0.0594) for the dry season. The significant correlations were however very weak. This indicates that though IgG levels increased with age, the association between the antibody levels and age was not so strong and that the influence of age on the amount of antibodies produce against most of the antigens in the population studied was not that mu ch. However the age dependent increase in IgG response to the antigens tested may be due to the mature immune system in adults, and could also be due to cumulative exposure to infection over time (Nebie 2008). It is however not known what might be the reason for the lack of correlation with age to AMA1-3D7, and AMA1-FVO, in the wet and dry season respectively. IgG responses to the two AMA1 alleles (3D7, and FVO) was plotted against each other to determine which is more predominant in the study population. There was a strong correlation between the antibody levels of AMA1 alleles of 3D7 and FVO (r2=0.8382, p) implying that both strains are circulating in the study site during the wet season. A similar trend was observed in the dry season but with a lower correlation coefficient compared to the wet season (r2= 0.5302, p). Antibody titres against recombinant antigens have often been linked to protection from clinical disease (Polley 2004, Nebie 2008, Dodoo 2008, Dodoo 1999, Cavanagh 2004). Where high anti-malaria antibodies is interpreted to mean protection from clinical disease. The important role of antibodies was demonstrated by the passive transfer of purified IgG from immune donors to individuals with P. falciparum infection, which reduced parasitaemia (Cohen 1961, sabchareon 1991). Apical membrane antigen-1 AMA1 and MSP119 have been associated with reduced risk of clinical malaria (Branch 1998, Osier et al 2008). Anti-CSP antibodies have also been found to be partially protective where in Kenya high anti-CSP, anti-LSA, and anti-TRAP ( pre-erythrocytic ) antibodies were demonstrated to be associated with relative protection from reinfection (John CC 2005, 2008). The most advance malaria vaccine, RTS’S which is a subunit of CSP, has been found to protect to about 35-55% in children 5-17 mont hs for about 8 months (Alonso 2004,) . Also anti-CelTOS antibodies have been shown to inhibit invasion of herpatocytes by sporozoites in mice (Bergmann-Leitner 2010). In this study, antibody responses to the antigens, AMA1-3D7, AMA1-FVO, MSP119, CSP, and CelTOS were determined using indirect ELISA. The optical densities (OD) of the antigens were converted to arbitrary units (AU) where the highest OD for each antigen was awarded an arbitrary unit of 4, to allow for comparison between antigens the antigens tested. Antibodies to AMA1 in individuals living in malaria endemic regions have been reported to be high, (Thomas,1994, chelimo, 2005), and this study thus reports high antibodies to AMA1-3D7, and AMA1-FVO compared to MSP1(19), CSP, with anti-CelTOS antibodies being the least. (Fig: 3) in both wet and dry seasons. The data also shows total IgG responses in the wet season was higher than the in the dry season for all the antigens (p) except MSP119 where no statistical differences wa s found between the two seasons (p=0.85) (Figure 3). The seasonal changes in antibody response could be as a result of higher number of vector (mosquitoes) in the community in the wet season which could in turn increase the exposure of the population to parasites and also introduce new parasite clones/strains in the population and hence the high anti-malaria antibodies found in the wet season. In contrast, the dry season cause a reduction in the number of breeding sites for the vectors reducing their population resulting in minimal exposure and hence the low antibody levels. In malaria endemic regions, the number of different clones of Plasmodium falciparum parasites infecting a person could be a transmission indicator, an indicator of the hosts immune status, and a useful parameter in evaluating malaria control interventions (Babiker 1999, Arnot 1998, mayengue 2009). It has also been reported that parasite diversity in high malaria transmission areas are high and that individuals could carry multiple genotypes (clones) but the opposite pertains in low endemic areas with most infections being monoclonal (Peyerl-Hoffmann 2001, Bakiker 1997, Haddad 1999). Genotyping was done using block 3 region of the MSP 2 gene (Smythe et al. 1990) because of its high polymorphic nature (Felger et al.,1994 1999; Robert et al., 1996). Also MSP2 was selected to be used for this study because of the high allelic diversity observed in Ghana and other countries bordering Ghana with as many as 154 alleles in Ghana and about 50 genotypes in CÃ ´te d’Ivoire. ( Silue 2006 , falk 2006). The results from the two seasons using the 3D7 allelic family primers showed high mean multiplicity of infection in the wet season compared to the dry season (1.76, and 1.46, p=0.001) table 3. In both seasons, the number of infections per person ranged from 0 to 4. A similar degree of multiple infections has been reported in other African settings (Ntoumi et al., 1995,Beck 1997, Engelbrecht 1999). The samples used for this study was collected in asymptomatic individuals and the high multiplicity of infection found in the wet season could probably be due to high rate of exposure as a result of favourable breeding conditions compared to the dry season. This study did not find any significant correlation between MOI and age in both seasons (p=0.5768 for wet season, and p=0.4158 for the dry season). The samples were then grouped into two based on whether positive or negative using PCR to detect Plasmodium parasites. No differences were detected in the IgG levels between th e antigens tested in both seasons when compared based on the PCR data. This result is similar to that found when microscopy was used except that anti-CelTOS IgG in the parasitaemic group was higher than the non-parasitaemic group when microscopy was used. The disparity in the CelTOS report could be due to the lower sample size analysed using PCR compared to the microscopy. Apical membrane antigen AMA1 has been found to be a promising blood stage vaccine candidate antigen but this potential has been dampen due to extensive polymorphism (Remaque 2008).

Physiological Effects Of Chronic Stress On Personality Psychology Essay

Physiological Effects Of Chronic Stress On Personality Psychology Essay Stress can cause physical effects to a persons body and mind. Stress may have an effect on blood pressure, blood sugar levels, increased heartbeat, and a lower digestive rate. On a physical level stress can produce shoulder, back, and neck muscle tension, stomach and bowel upset, and if the stressful state persists over a long period of time it can lead to the weakening of the immune system (What are the Effects of Stress, 2007). Stress affects a person psychologically by causing a decrease in concentration, moodiness, irritability, quick temper, unreasonable anger, less memory recall, less patience difficulty making decisions, and uncertainty towards the future due to not being able to cope with the present. If stress continues for a long period of time, it may lead to depression, crying, apathy, overall sense of doom, fear of failure, and a loss of confidence (What are the Effects of Stress, 2007). There have been many studies done that have researched the effects of stress on the mind and body. The causes of stress and the effects that it has on a persons mind and body are numerous. Some of these will be looked at in detail here. Job stress is one that can lead to various system dysfunctions, but until now no reliable biomarkers for its assessment have been identified. Allostatic load (AL) is an index that allows the cumulative effect on the body of chronic stress to be reviewed, and is derived from a set of relevant biological measures. In a study done by Sun, Wang, Zhang and Li (2007), a 13-parameter index was used to examine the relationship between job strain and AL. Participants were 1219 healthy Chinese employees. Job strain was measured using the Job Content Questionnaire, and AL was assessed by various possible stress responses, including blood pressure, cholesterol, indicators of glucose metabolism, and hormone and inflammation markers. AL in the high job strain group differed sharply from that in the low job strain group. The AL score was positively linked with age and educational level. Several individual factors also differed between the two groups. Men scored considerably higher on AL and cardiovascular and metabolic health outcomes, whereas for women the associations appeared in the biological indicators. Analyses showed that decision latitude (DL) and job demands were extensively related to AL. Job demands connected significantly with the primary biological indicators and DL with the secondary health outcomes. The conclusion of this study provided evidence of the value of measuring allostatic load in assessing the chronic effects of job stress. Job strain was positively and significantly associated with higher body mass index, systolic blood pressure, serum levels of TG, TC/HDL, and overnight excretion of cortisol. It was also found that long-term chronic stress may lead to neuroendocrine perturbations that may have consequences for blood pressure and obesity (Sun, Wang, Zhang and Li, 2007). Nursing is an emotionally demanding job and this contributes to interactive stress and to the daily stress of nurses work. In addition, stress leads to more emotion focused coping which is not constructive and causes nurses to seek social support. Stress is a normal reaction to a range of circumstances but can have negative consequences, one of which is emotional exhaustion; it has been demonstrated that factors leading to stress, such as increasing patient load, also lead to emotional exhaustion. The aim of a study done by Watson, Gardiner, Hogston, Gibson, Stimpson, Wrate and Deary, 2009), was to examine how a range of demographic, personal, circumstantial/environmental factors and stress contribute to differences in psychological distress in newly qualified nurses and nursing students. Psychological distress, stress levels and life events are all associated within time and across time. It was shown that life events and stress contributed significantly to psychological distress. S tress, adverse life events, individual traits and psychological distress are all interrelated. The first scientific report regarding physiologic responses to stress was actually submitted in response to Walter Cannons study on the results of stress on the esophagus in 1896. It was during his first year as a Harvard medical student, he had been given the task to investigate the mechanisms of swallowing by taking advantage of the newly discovered Roentgen rays. These x-rays could show a faint image of inner body structures using a fluoroscope, but it was essential to sit in a very dark room or wear red goggles to get the best pictures. Cannon included bismuth in foods since it was opaque and blocked x-rays, which noticeably improved his ability to differentiate the peristaltic motion of waves that progressively propelled the contents of the gut forward. Bismuth was subsequently replaced by barium sulfate, which was less toxic, and is still used in GI series, barium enemas and other x-ray imaging procedures today (Rosch, 2007). His study showed that there was a definite connectio n between stress and the way in which the esophagus functioned. Chronic psychosocial stress can lead to a destructive, self-perpetuating cascade of neuroendocrine, metabolic, inflammatory, and neuropsychological changes that promote the development of insulin resistance syndrome (IRS), atherosclerosis, and ultimately, cardiovascular disease (CVD). Chronic stress and related psychosocial factors can exert a powerful influence on the pathogenesis of both IRS and CVD. Given the importance of neuropsychological factors and sympathetic activation in the development of insulin-resistant states and the synergistic, mutually exacerbating effects of these and other IRS-related risk factors, mind-body therapies may have considerable potential in the prevention and management of CVD (Innes, Vincent and Taylor, 2007). Anxiety and tension encourage the release of stress hormones like adrenaline, norepinephrine and cortisol into the body. This is fine when dealing with short-term stressors, but when a person sustains a high stress level for an extended time, these hormones begin to interfere with the bodys natural healing abilities. Over an extended period of time, a high level of stress can weaken tendons and ligaments, thin bones, cause muscle spasms, elevate blood pressure, increase cholesterol production and disrupt digestion, among many other negative effects (Dennis, 2004). Recent studies have shown that stress or distress may have a significant effect on the onset, the course, and the management of many, if not all, diseases. Being able to understand a patients underlying stress physiology and coping mechanisms may help physicians to better understand various clinical disorders and treat their manifested symptoms (Selhub, 2002). The primary-care physician can learn to address and recognize distress by first understanding the concept of stress itself. Not just a result of medical illness, stress is ever present. In the workplace, while driving, while speaking on the phone, while visiting the doctors office, or while watching world events transpire on television, individuals experience stress or feel threatened daily. These threats or stressors can be as minor as a change in the weather and the threat of being late, to more severe stressors, such as physical or emotional trauma or abuse. The mind does not distinguish between physical, psychological, or emotional threats and every time a threat is perceived, the physical response is virtually automatic; a response that is activated in order to help the individual adapt to stressors and survive. In fact, stress and the stress response are inherent to life. The response helps individuals rise out of bed in the morning, prevents them from being late to work, and a llows them to be accomplished and to succeed. The response enables wounds to heal, athletes to run marathons, and individuals to survive traumas (Selhub, 2002). Often, the stress response is neither well regulated nor contained and pathological consequences arise. Constant elevations in blood pressure and blood volume can result in wall thickening and tears. Excess production of fatty acids and glucose may lead to deposition in these tears and formation of atherosclerotic plaques, eventually resulting in atherosclerotic heart disease. Constant muscle tension and/or inflammatory activation may instigate various pain and musculoskeletal disorders. Chronic production of cortisol can lead to immunosuppression and increased susceptibility to infection and, some believe, tumors. Lack of blood flow to the gastrointestinal (GI) tract and an increase in hydrochloric acid secretion may result in destruction of mucosal wall barriers and formation of peptic ulcer disease. Continuous production of cortisol may also decrease the availability of tryptophan, the precursor for serotonin, resulting in depression, other mood disorders, and changes in appetite and sleep. Hyperactivity of the stress response has been implicated in the pathophysiology of melancholic depression, anxiety, diabetes, gastrointestinal disorders, obsessive-compulsive disorders, substance abuse, eating disorders such as anorexia nervosa, and cardiovascular disease. Conversely, hyporeactivity of the stress response has been associated with disorders such as atypical depression, chronic fatigue syndrome, hypothyroidism, and obesity (Selhub, 2002). It has been shown that there is a definite connection between chronic stress and physical and psychological responses in the body. Stress in small amounts is fine, but chronic stress over a long extended period of time has been shown to manifest itself in a number of different physical and physiological aliments. It is believed by many experts that people should take steps to decrease their stress levels in order to fight off the ailments that are sure to follow.

The Literary Merit of Animal Farm Essay -- Animal Farm

The Literary Merit of Animal Farm      Ã‚  Ã‚   The year of 1945 marked a great turning point in world history.   The end of the Second World War, the detonation of the atomic bomb, the beginning of the Cold War took place during that year.   Also in 1945, George Orwell published Animal Farm, The book drew wide interest due to its scathing commentary on the Russian communist movement at a time when Britain and Russia were still allies.   The body of criticism relating to the novel is among the greatest of twentieth century literature.   Attacking the work from a variety of angles, every detail has been poked and prodded, but the consensus is still out on how best to judge Orwell's book.   By analyzing the usage of simple themes, comparisons to the Russian communist movement, and the usage of animal allegory in George Orwell's Animal Farm, its overall literary value may be evaluated.      Ã‚  Ã‚   One of the hallmarks of Animal Farm is its thematic simplicity.   Set on a farm in rural Britain, the book chronicles the history of the farm's animals and their revolution against humans.   From its chaotic beginnings, the revolution is able to defend itself against its enemies and make technological leaps.   However, a rigid hierarchy is soon forged which so resembles the ante-bellum totalitarian leadership of Farmer Jones that "the creatures outside looked from pig to man... but already it was impossible to say which was which," (Orwell 128).   Orwell's smooth and simple narrative is clear-cut and easy to understand, which adds to the overall appeal of the book.      Ã‚  Ã‚   However, some critics interpret this very simplicity as a weakness.   They hold that by making such broad generalizations of very complex situations, the merit of Animal Fa... ...asured in the years to come.    Works Cited: Alldritt, Keith. The Making of George Orwell. New York: St. Martin's Press, 1961. Meyers, Jeffrey, ed. George Orwell: The Critical Heritage. London: Routledge & Kegan Paul, 1975. Orwell, George. Animal Farm. Signet 50th Anniversary Edition, Harcourt Brace & Company, 1996. Zwerdling, Ales. Orwell and the New Left. New Haven, CT: Yale University Press, 1974.    Works Consulted: Bloom, Harold, ed. George Orwell's Animal Farm. New York: Chelsea House Publishers, 1999. Davison, Peter. George Orwell: A Literary Life. New York: St. Martin's Press, 1996. Fowler, Roger. The Language of George Orwell. New York: St. Martin's Press, 1995. Gross, Miriam, ed. The World of George Orwell. London: Weidenfeld and Nicolson, 1971. Williams, Raymond. Orwell. London: Fontana Press, 1991.

Are tall buildings necessary for London to remain a competitive world c

Are tall buildings necessary for London to remain a competitive world city? On February 10, 2004 mayor of London Ken Livingstone introduced the London Plan, the first proactive strategy in over thirty years to deal specifically with the planning and development of London. Since an increase in London's population by 800,000 is expected by the year 2020 , the mayor has suggested the construction of high-rise buildings as the method most likely to enable London to grow in a controlled and steady manner and maintain its status as a world city. A key part of the plan, the mayor's proposal for high-density towers throughout the city, has heightened the debate between urban planners and heritage groups as to whether the construction of tall office and housing complexes is necessary and/or appropriate for London. Based on recent documents, articles and essays and London's need to remain competitive with New York and Tokyo as a world class city, the construction of tall buildings in London is a necessity, especially due to certain factors such as the need to preserve historic views, the lack of available space and London's poor transport system. The ongoing debate over whether tall buildings would best serve London and sustain and enhance its status as a world-class city has dominated the political and metropolitan structural-design arenas during the last ten years. On one side are heritage groups and conservationists claiming that an increase in the number of tall buildings would block strategic views of London's historically significant landmarks. For example, the organization English Heritage has stated that the tall buildings are a cultural issue and their role is first and foremost of image and aesthetics rather than economic,... ...22, 16 February 2004 Government of London, 'London's skyline, views and high buildings,' Planners and Development Economists http://www.london.gov.uk 16 February 2004 Government of London, 'The London Plan.' Ken Livingstone. http://www.london.gov.uk 17 February 2004 Hamnett, 'The transformation of London's occupational structure and the rise of the new middle class,' Unequal City. (Routledge) pp. 70 Livingstone, Ken. 'The only way is up,' The Independent. 2 November 2002. London School of Economics, 'London should grow up says new report on tall buildings' http://www.lse.ac.uk/collections/pressAndInformationOffice/newsAndEvents/ archives/2000-2002/Tall_Buildings.htm 13 February 2004 Newman, P, Thornley, A. 'Fragmentation and centralization: Influencing the urban policy agenda in London' Urban Studies 34. The Editors of Urban Studies: 2997. pp 981

Stereochemistry: Addition of Bromine to Trans-Cinnamic Acid

STEREOCHEMISTRY: ADDITION OF BROMINE TO trans-CINNAMIC ACID Required Prelab Readings:McMurry Chapter 5, Sections 8. 2 & 21. 2 Morhig, Sections 7. 1 and 7. 3. Previous techniques that you must know and be able to perform: Suction Filtration and Melting Point This experiment is designed to demonstrate two concepts. First, it will provide a demonstration of how chemists can use chemical reactions to understand reaction mechanisms. Second, is the concept of multi-step synthesis. You will be performing the following reaction: Isomer IIsomer II + Enantiomer+ EnantiomerBrominetrans-Cinnamic Acid2,3-Dibromo-3-phenylpropanoic acid MW 160 g/molMW 148 g/molMW 308 g/mol bp 60  °Cmp 133-134  °Cmp 93-95  °Cmp 202-204  °C When an electrophile, such as bromine, adds to an alkene, the addition can be done in a syn fashion, in which the two groups add to the same side of the molecule, or in an anti fashion, in which the groups add to opposite sides of the molecule. Depending on the mode of add ition, syn or anti, and the stereochemistry of the starting alkene, various stereoisomers will result. In some cases, a racemic mixture of products is formed, other times a meso compound is produced. Feature Article –  Free-Radical BrominationThe Fischer projections shown above are two possible stereoisomers that could form in the bromination reaction that you will perform. One is the result of a syn addition, the other is the result of an anti addition mode. Note that each would form as a racemic mixture, (+). You are to determine, based on the melting point of your product, which pair of enantiomers is produced. By knowing which enantiomeric pair is formed one can predict a plausible mechanism. Hint: you can predict the stereochemical outcome of a syn vs. anti addition of bromine to alkenes before you step foot into the laboratory.The simplest example of a multi-step synthesis is to examine virtually any commercial medicine. Almost without exception that medicine was prepared by a series of reactions rather than in a single step. A multi-step synthesis generally requires a chemist to perform a chemical reaction, isolate, purify and characterize the product and then use that product as the starting material for the next reaction. You will be using the product of this reaction as your starting material next week. It will be important for you to have the product from this week properly identified so you can correctly predict the product of next week’s reaction. The most time-consuming part of this experiment is setting up the glassware. Be sure all fittings are tight, well-greased, and clamped so as to prevent any escape of bromine vapors into the laboratory environment. An actual set-up is provided for you in the lab for you to look at. ? You will need to set up the apparatus as shown in figure 7. 4 a on page 63 of Mohrig. NOTE:You are responsible for calculating the amount of trans-cinnamic acid (in grams) equivalent to 4  mmol. You must have this done before you enter the lab. HazardsMolecular bromine is extremely toxic and corrosive; its vapors are damaging to the skin eye and respiratory tract. Wear gloves and UNDER NO CIRCUMSTANCES AR E YOU TO REMOVE THE BROMINE STOCK SOLUTION FROM THE HOOD. Only remove your bromine solution in the stoppered funnel. Sodium thiosulfate reduces Br2 to Br-1. When working with Br2, always keep a bottle of 5% sodium thiosulfate handy for rinsing the skin in case of contact. Experimental ? Assemble a 50 mL round-bottom flask with a Claisen head, reflux condenser, and addition funnel. Into the round-bottom flask, add trans-cinnamic acid (4 mmol) and 10 mL of methylene chloride.Add a stir bar. ? Obtain 4. 0 mL of a 1. 0 M solution of bromine in methylene chloride in the addition funnel. Attach a heating mantle and variac and heat the mixture to a gentle reflux. The variac setting should initially be 25-30. Adjust this setting as necessary until the solution is refluxing . ? While it is refluxing, add the bromine solution at a rate of two drops per second. You need not loosen the stopper on the funnel for the bromine addition due to the high density of methylene chloride. The red-orange c olor of the bromine should dissipate as it reacts with the mixture.Continue to reflux for an additional 10 minutes after the last of the bromine has been added. ? The color of your final solution should be a very pale yellow. If the red-orange color persists after the 10 min, add cyclohexene dropwise (1-2 mL) until the red color disappears. ? Remove the reaction flask and cool it in an ice bath for 10 minutes with a greased stopper on top. Allow the product, 2,3-dibromo-3-phenylpropanoic acid, to crystallize. ? Meanwhile, disassemble the rest of the reflux apparatus and sit it in the back of your hood to allow the fumes to dissipate.Rinse the glassware with a small amount of sodium thiosulfate to destroy any remaining bromine. ? Collect the crystalline product by suction-filtration, and rinse with a minimal amount of ice-cold methylene chloride. Allow it to air-dry and record the mass and melting range of the product. Have your instructor check the weight of your product and initial this value in your lab notebook. Save all of your product as it is the starting material for next week. STEREOCHEMISTRY: Addition Of Bromine To trans-Cinnamic Acid DATA SHEET NAME: Section Number: Overall Reaction (including stereochemistry, Symyx Draw): Mass of acid: Theo mmol product: mmol of acid:Theo mass product: Volume of Br2 sol’n: Mass recovered product: mmol of Br2: mmol recovered product: % yield of product: Melting point of recovered product: Literature melting point: Calculations: (notebook) Post Lab Questions 1. What is the stereochemical relationship between Isomer I and Isomer II? 2. Use perspective drawings, Fischer Projections and words, to demonstrate whether syn addition of bromine to trans-cinnamic acid results in Isomer I or Isomer II. Repeat the process for anti addition. NOTE CAREFULLY:The question is about mode of addition (syn vs. anti), not mechanisms; do not use curved arrows to explain your answer.3.Based on your results, did the addition occur by a syn or anti mode? Explain your reasoning. 4. Provide the â€Å"electron-pushing† mechanism for this reaction and show how both enantiomers are produced. Use perspective representations to draw structures. Assign the R / S configuration to each stereocenter in the products. 5. Using perspective drawings with the correct stereochemistry, redraw the pair of enantiomers you drew in question 4 and show how each can be redrawn as the Fischer projection of Isomer I, Isomer II, or the enantiomer. Clearly label all stereocenters as R or S. 6. Show the products of the following electrophilic addition reactions (symyxdraw):

Importance of Literature

ENG 101 7 February 2012 Importance of Literacy Literature is a creative and imaginative type of writing. It is a source of information that leads to the guiding principles of life. Having the knowledge to read literature attentively and understand it is extremely important. Literacy is not optional, it is necessary. Literature is not just reading a text but being able to reflect upon it. There are many different types and forms of literacy. Some come in forms of poems and others as dramas or films. Literacy expands towards many varieties.There are children literatures such as â€Å"Winnie the Pooh† and there are also more sacred types of literature such as the scripter’s or Holy Bible. Reading or watching literature gives a person a chance to experience different thoughts towards different situations, it opens a persons mind to imagination. Understanding literature is a sign of intelligence and knowledge. It is not always simple to understand and reflect on literacy. It is important to be open-minded when reading or watching literature.Philosopher Edmund Burke once said, â€Å"Reading without reflecting, is like eating without digesting. † For all means philosopher Burke is one hundred percent correct. The ability to reflect on what is being told shows intelligence, it shows that you have not only read word by word, but you have read the whole piece as one. There are many mistakes that are caused by illiterate people. A perfect example of this concept is the story of a man who was responsible for the death of his son.In the essay â€Å"Hunger in America†, written by Richard Mitchell, Bill Barnhart was charged for certain criminal acts towards his sons death. Barnhart used a passage from the bible for his defense in the case. He believed that in the bible God said that no one should use any medication whatsoever. His son was sick and Barnhart refused to treat his son. His misunderstanding of what was being said cost his sons life. Bei ng literate is extremely important. It can affect everyone around you. Learning literacy is a task that can take a while, but it is not impossible.Reading is extremely important; it is the basics in life. Sense everything requires reading words, the only thing that remains is the reflecting part. Reflecting what you have read shows that you have a clear understanding of what is being said. To be literate does not mean that a person has to read novels and books. It could be simply by reading the news paper, and article, or even a magazine or watching a film. As long as you take time to reflect on the information given and understand what is given, you can read whatever you wish to.Reading or watching literacy gives a person a chance to experience different thoughts towards different situations, it opens a persons mind to imagination. The understanding of literature brings many good things to us, either in science or entertainment. Everything that our world is built on has been based on literacy and continues to do so. Being literate is required to humankind, it is important that we all understand obstacles and situations in life. Literacy allows us to have an idea on how different people live their lives, and it also helps us to understand the purpose in our own life.